The total cross sections for K-shell ionization of targets, Arsenic and Yttrium (i.e., As & Y), have been calculated due to electron impact at the incident electron energy from ionization threshold to 1 GeV by using the theoretical Khare method modified by Y Kumar et al.3. This method is based on plane wave Born approximation. The calculated cross sections have been compared with the available experimental data and other theoretical cross sections. The present calculated cross sections are in excellent agreement with measured by Merlet C. et al. 15 and Hoffmann et al.22 for As. A good agreement is found between the present calculations and measured Luo Z. et al.21, Ishii K. et al.23 for Y