Software is an integral part of many critical and non-critical applications, and virtually any industry is dependent on computers for their basic functioning. Techniques to measure and ensure reliability of hardware have seen rapid advances, leaving Software as the bottleneck in achieving overall system reliability. Hence there rises a situation for the developers to develop high quality software. Having that in mind it is necessary to provide the reliability of the software to the developers before it is shipped. This can be achieved based on immune system. The immune system that is otherwise known as 'second brain' for its abilities to recognize new intruders and remember past occurrences. Simulating the immune system or translating immune system mechanisms into software learning is an interesting topic on its own. This will produce high quality, reliable results over a wide variety of problems compared to a range of other approaches, without the need of expert fine-tuning.