In this manuscript a study of the unsteady magneto-hydrodynamic mixed convection Jeffrey fluid flow over an inclined permeable moving plate in presence of thermal radiation, heat generation, thermophoresis effect and homogenous chemical reaction, subjected to variable suction has been undertaken. The governing equations are solved by using a regular perturbation technique. The expressions for the distributions of velocity, temperature and species concentration are obtained. With the aid of these, the expressions for skin friction, Nusselt number and Sherwood number also have been derived. The influences of various physical parameters involved in the problem on the above mentioned quantities are discussed with the help of graphs and tables. From the significant findings, it has been found that the velocity increases with an increase in Soret number in the presence of permeability. It shows reverse effects in the case of heat absorption coefficient, magnetic parameter, radiation parameter and chemical reaction parameter.